Frostbite. Methods to minimize tissue loss

Postgrad Med. 1990 Dec;88(8):67-8, 73-7. doi: 10.1080/00325481.1990.11704769.


If frostbite is to be treated successfully, direct and indirect effects of injury must be understood. Rapid rewarming helps to preserve tissue by limiting the amount of direct cellular injury. Selective management of blisters helps protect the subdermal plexus, and application of Aloe vera cream (eg, Dermaide Aloe Cream) combats the local vasoconstrictive effects of thromboxane. Oral administration of ibuprofen decreases systemic levels of thromboxane.

MeSH terms

  • Aloe
  • Analgesics / therapeutic use
  • Clinical Protocols*
  • Combined Modality Therapy
  • Debridement
  • Dermatologic Agents / therapeutic use
  • Frostbite / classification
  • Frostbite / therapy*
  • Humans
  • Hydrotherapy
  • Ibuprofen / therapeutic use
  • Penicillins / therapeutic use
  • Plants, Medicinal


  • Analgesics
  • Dermatologic Agents
  • Penicillins
  • Ibuprofen