Amelioration of ionizing radiation induced lipid peroxidation in mouse liver by Moringa oleifera Lam. leaf extract

Indian J Exp Biol. 2012 Mar;50(3):209-15.

Abstract

Protective effect of Moringa oleifera leaf extract (MoLE) against radiation-induced lipid peroxidation has been investigated. Swiss albino mice, selected from an inbred colony, were administered with MoLE (300 mg/kg body wt) for 15 days before exposing to a single dose of 5 Gy 60Co-gamma radiation. After treatments, animals were necropsied at different post irradiation intervals (days 1, 7 and 15) and hepatic lipid peroxidation and reduced glutathione (GSH) contents were estimated to observe the relative changes due to irradiation and its possible amelioration by MoLE. It was observed that, MoLE treatment restored GSH in liver and prevented radiation induced augmentation in hepatic lipid peroxidation. Phytochemical analysis showed that MoLE possess various phytochemicals such as ascorbic acid, phenolics (catechin, epicatechin, ferulic acid, ellagic acid, myricetin) etc., which may play the key role in prevention of hepatic lipid peroxidation by scavenging radiation induced free radicals.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Free Radical Scavengers / metabolism
  • Free Radical Scavengers / pharmacology
  • Humans
  • Hydroxyl Radical / metabolism
  • Lipid Peroxidation / drug effects*
  • Lipid Peroxidation / radiation effects*
  • Liver* / drug effects
  • Liver* / metabolism
  • Liver* / radiation effects
  • Male
  • Mice
  • Moringa oleifera / chemistry*
  • Plant Extracts / metabolism
  • Plant Extracts / pharmacology*
  • Radiation, Ionizing*
  • Radiation-Protective Agents / metabolism
  • Radiation-Protective Agents / pharmacology*
  • Thiobarbituric Acid Reactive Substances / metabolism

Substances

  • Free Radical Scavengers
  • Plant Extracts
  • Radiation-Protective Agents
  • Thiobarbituric Acid Reactive Substances
  • Hydroxyl Radical