We present two new cases of Y-autosome translocation which were detected in two azoospermic males. In the first case the translocation was de novo with the karyotype: 46,XY,t(Y;16)(q12;q11-12). In the second case the karyotype was: 46,XY,t(Y;1)(cen-q11;cen-p11), t(Y;15)(q12;p11), the mother having been a carrier of the same Y-15 translocation, and showing the chromosomic formula: 46,XX,t(Y;15)(q12;p11).