Habitual alcohol seeking: time course and the contribution of subregions of the dorsal striatum

Biol Psychiatry. 2012 Sep 1;72(5):389-95. doi: 10.1016/j.biopsych.2012.02.024. Epub 2012 Mar 20.


Background: Addictions are defined by a loss of flexible control over behavior. The development of response habits might reflect early changes in behavioral control. The following experiments examined the flexibility of alcohol-seeking after different durations of self-administration training and tested the role of the dorsal striatum in the control of flexible and habitual alcohol self-administration.

Methods: Rats were trained to lever-press to earn unsweetened ethanol (EtOH) (10%). The sensitivity of the lever-press response to devaluation was assessed by prefeeding the rats either EtOH or sucrose before an extinction test after different amounts of training (1, 2, 4, and 8 weeks). We subsequently tested the role of the dorsomedial striatum (DMS) and dorsolateral striatum (DLS) in controlling alcohol seeking with reversible inactivation techniques (baclofen/muscimol: 1.0/.1 mmol/L, .3 μL/side).

Results: We find that operant responding for EtOH early in training is goal-directed and reduced by devaluation, but after 8 weeks of daily operant training, control has shifted to a habit-based system no longer sensitive to devaluation. Furthermore, after relatively limited training, when responding is sensitive to devaluation, inactivation of the DMS greatly attenuates the alcohol-seeking response, whereas inactivation of the DLS is without effect. In contrast, responding that is insensitive to devaluation after 8 weeks of training becomes sensitive to devaluation after inactivation of the DLS but is unaffected by inactivation of the DMS.

Conclusions: These experiments demonstrate that extended alcohol self-administration produces habit-like responding and that response control shifts from the DMS to the DLS across the course of training.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Animals
  • Behavior, Addictive / physiopathology*
  • Conditioning, Operant / drug effects*
  • Conditioning, Operant / physiology
  • Corpus Striatum / drug effects*
  • Corpus Striatum / physiology
  • Ethanol / pharmacology*
  • Extinction, Psychological / drug effects*
  • Extinction, Psychological / physiology
  • Habits
  • Learning / physiology*
  • Male
  • Models, Animal
  • Rats
  • Rats, Long-Evans
  • Self Administration


  • Ethanol