LRRK2 as a Modulator of Lysosomal Calcium Homeostasis With Downstream Effects on Autophagy

Autophagy. 2012 Apr;8(4):692-3. doi: 10.4161/auto.19305. Epub 2012 Apr 1.


Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Cell Survival
  • Drosophila melanogaster / enzymology
  • Homeostasis*
  • Lysosomes / metabolism*
  • Models, Biological
  • NADP / analogs & derivatives
  • NADP / metabolism
  • Phagosomes / metabolism
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*


  • Calcium Channels
  • NADP
  • Protein-Serine-Threonine Kinases
  • Calcium