LRRK2 as a Modulator of Lysosomal Calcium Homeostasis With Downstream Effects on Autophagy

Autophagy. 2012 Apr;8(4):692-3. doi: 10.4161/auto.19305. Epub 2012 Apr 1.

Abstract

Alterations in autophagy are thought to underlie various neurodegenerative diseases including Parkinson disease (PD). Previous studies have indicated that the PD gene leucine rich repeat kinase 2 (LRRK2) is involved in this process, but its mechanism of action has remained unknown. Our recent work describes how LRRK2 acts through calcium-mediated events originating from acidic stores to regulate autophagy and cell survival, which may give rise to novel therapeutic strategies.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Autophagy*
  • Calcium / metabolism*
  • Calcium Channels / metabolism
  • Cell Survival
  • Drosophila melanogaster / enzymology
  • Homeostasis*
  • Lysosomes / metabolism*
  • Models, Biological
  • NADP / analogs & derivatives
  • NADP / metabolism
  • Phagosomes / metabolism
  • Protein-Serine-Threonine Kinases / metabolism*
  • Signal Transduction*

Substances

  • Calcium Channels
  • NADP
  • NAADP
  • Protein-Serine-Threonine Kinases
  • Calcium