Human induced pluripotent stem cells derived hepatocytes: rising promise for disease modeling, drug development and cell therapy

Protein Cell. 2012 Apr;3(4):246-50. doi: 10.1007/s13238-012-2918-4. Epub 2012 Mar 22.


Recent advances in the study of human hepatocytes derived from induced pluripotent stem cells (iPSC) represent new promises for liver disease study and drug discovery. Human hepatocytes or hepatocyte-like cells differentiated from iPSC recapitulate many functional properties of primary human hepatocytes and have been demonstrated as a powerful and efficient tool to model human liver metabolic diseases and facilitate drug development process. In this review, we summarize the recent progress in this field and discuss the future perspective of the application of human iPSC derived hepatocytes.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Cell Differentiation
  • Cell- and Tissue-Based Therapy
  • Drug Evaluation, Preclinical
  • Hepatocytes / cytology*
  • Humans
  • Induced Pluripotent Stem Cells / cytology*
  • Induced Pluripotent Stem Cells / transplantation
  • Liver Diseases / therapy
  • Models, Biological*