Prevalence of noncardiac structural anomalies in twin-twin transfusion syndrome

J Ultrasound Med. 2012 Apr;31(4):555-60. doi: 10.7863/jum.2012.31.4.555.


Objectives: Compared to singleton pregnancies, monochorionic twins have increased rates of perinatal morbidity and mortality, believed due in part to both twin-twin transfusion syndrome and an increased risk of congenital anomalies. Here we describe the prevalence of noncardiac structural anomalies in monochorionic twins with twin-twin transfusion syndrome who underwent laser surgery.

Methods: In a retrospective study of 221 consecutive cases of twin-twin transfusion syndrome treated with laser surgery, noncardiac anomalies were identified by review of antepartum and neonatal medical records.

Results: Of 377 live-born twins, 19 (5.0%) had a noncardiac anomaly. This rate was increased for donor versus recipient twins (8.5% versus 2.0%; P < .01). The presence of an anomaly was unrelated to the Quintero stage, the presence of donor intrauterine growth restriction, or 30-day survival of the donor or recipient.

Conclusions: The prevalence of noncardiac anomalies in pregnancies complicated by twin-twin transfusion syndrome who underwent laser surgery was higher in donors versus recipients.

MeSH terms

  • Abnormalities, Multiple / diagnostic imaging*
  • Abnormalities, Multiple / epidemiology*
  • Comorbidity
  • Female
  • Fetofetal Transfusion / diagnostic imaging*
  • Fetofetal Transfusion / epidemiology*
  • Humans
  • Infant, Newborn
  • Los Angeles / epidemiology
  • Male
  • Prevalence
  • Risk Assessment
  • Risk Factors
  • Ultrasonography