Psychoimmunomodulatory Effect of Phenotropil in Animals With Immune Stress

Bull Exp Biol Med. 2011 May;151(1):51-4. doi: 10.1007/s10517-011-1257-4.

Abstract

We studied the effect of phenotropil (25 mg/kg intraperitoneally, 5 days) on the immune and psychoemotional state of Wistar rats with LPS-induced immune stress. Hyperactivity of the immune system in animals after treatment with Pseudomonas aeruginosa LPS (100 μg/kg intraperitoneally, 3 days) manifested in a significant increase in the delayed-type hypersensitivity index, antibody titer in the reaction of passive hemagglutination, and phagocytic activity of peripheral blood neutrophils. Locomotor, orientation, and exploratory activities were reduced, while anxiety increased in animals with immune stress. Phenotropil exhibited the psychoimmunomodulatory effect under these conditions, which manifested in prevention of anxiety and fear response, increase in horizontal locomotion and exploratory behavior, and improvement of immunoreactivity.

MeSH terms

  • Animals
  • Antibodies / immunology
  • Anxiety / chemically induced
  • Anxiety / drug therapy*
  • Anxiety / immunology
  • Behavior, Animal / drug effects
  • Hemagglutination Inhibition Tests
  • Hypersensitivity, Delayed / chemically induced
  • Hypersensitivity, Delayed / drug therapy*
  • Hypersensitivity, Delayed / immunology
  • Immune System / drug effects
  • Immunomodulation
  • Injections, Intraperitoneal
  • Lipopolysaccharides / administration & dosage
  • Male
  • Maze Learning / drug effects
  • Motor Activity / drug effects
  • Neuroprotective Agents / administration & dosage
  • Neuroprotective Agents / therapeutic use*
  • Neutrophils / drug effects
  • Neutrophils / immunology
  • Phagocytosis / drug effects
  • Phagocytosis / immunology
  • Piracetam / administration & dosage
  • Piracetam / analogs & derivatives*
  • Piracetam / therapeutic use
  • Pseudomonas aeruginosa
  • Rats
  • Rats, Wistar

Substances

  • Antibodies
  • Lipopolysaccharides
  • Neuroprotective Agents
  • 4-phenylpiracetam
  • Piracetam