Standard Guidelines for the Chromosome-Centric Human Proteome Project

J Proteome Res. 2012 Apr 6;11(4):2005-13. doi: 10.1021/pr200824a. Epub 2012 Mar 26.

Abstract

The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-HPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing colocated genes and their protein products. The C-HPP aims to foster the development of proteome analysis and integration of the findings from related molecular -omics technology platforms through collaborations among universities, industries, and private research groups. The C-HPP consortium leadership has elicited broad input for standard guidelines to manage these international efforts more efficiently by mobilizing existing resources and collaborative networks. The C-HPP guidelines set out the collaborative consensus of the C-HPP teams, introduce topics associated with experimental approaches, data production, quality control, treatment, and transparency of data, governance of the consortium, and collaborative benefits. A companion approach for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome Project is currently being organized, building upon the Human Proteome Organization's organ-based and biofluid-based initiatives (www.hupo.org/research). The common application of these guidelines in the participating laboratories is expected to facilitate the goal of a comprehensive analysis of the human proteome.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Chromosomes, Human*
  • Databases, Protein / standards*
  • Guidelines as Topic
  • Human Genome Project*
  • Humans
  • Mass Spectrometry
  • Proteome / analysis*
  • Proteomics / methods*
  • Proteomics / standards*
  • Research Design

Substances

  • Proteome