Ten paths to the discovery of antivirally active nucleoside and nucleotide analogues

Nucleosides Nucleotides Nucleic Acids. 2012 Apr;31(4):339-52. doi: 10.1080/15257770.2012.657383.

Abstract

Nucleoside and nucleotide analogues have proven to be an effective approach toward the development of antiviral compounds. This approach has so far yielded a number of clinically useful antiviral drugs, such as BVDU (brivudin), (val)aciclovir, cidofovir, adefovir dipivoxil, and tenofovir disoproxil fumarate, and current perspectives justify the further development of other nucleoside analogues, such as FV-100, and that of the DAPy-based nucleotide analogues, the 5-aza analogue of cidofovir, and prodrug derivatives thereof.

Publication types

  • Historical Article

MeSH terms

  • Antiviral Agents / chemistry
  • Antiviral Agents / history*
  • Drug Discovery / history*
  • Drug Discovery / trends
  • History, 20th Century
  • History, 21st Century
  • Humans
  • Nucleosides / chemistry
  • Nucleosides / history*
  • Nucleotides / chemistry
  • Nucleotides / history*

Substances

  • Antiviral Agents
  • Nucleosides
  • Nucleotides