Dangerous liaisons: mitochondrial DNA meets the NLRP3 inflammasome

Immunity. 2012 Mar 23;36(3):313-5. doi: 10.1016/j.immuni.2012.03.005.

Abstract

Danger signals released by damaged organelles can promote inflammation. In this issue of Immunity, Shimada et al. (2012) report that oxidized DNA, released by mitochondria, directly binds and activates the NLRP3 inflammasome.

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