The role of the tec kinase Bruton's tyrosine kinase (Btk) in leukocyte recruitment

Int Rev Immunol. 2012 Apr;31(2):104-18. doi: 10.3109/08830185.2012.668982.


Recruitment of leukocytes into inflamed tissue is a key component of the immune system. The activation of integrins on leukocytes is required for their recruitment into the inflamed tissue. Btk is a cytoplasmic nonreceptor tyrosine kinase belonging to the Tec-kinase family. It plays a key role in B-cell development and function, and recently published studies revealed important roles of Btk in myeloid cells. Btk might be activated through a variety of receptors leading to activation of integrins as the pivotal element in leukocyte recruitment. This review focuses on the role of Btk in B-lymphocyte homing and in neutrophil recruitment.

Publication types

  • Review

MeSH terms

  • Agammaglobulinaemia Tyrosine Kinase
  • Animals
  • B-Lymphocytes / immunology*
  • Cell Movement
  • Humans
  • Inflammation / immunology*
  • Inflammation / metabolism
  • Lymphocyte Activation / immunology*
  • Mice
  • Neutrophil Infiltration / immunology*
  • Protein-Tyrosine Kinases / metabolism*
  • Signal Transduction


  • Protein-Tyrosine Kinases
  • Agammaglobulinaemia Tyrosine Kinase
  • BTK protein, human
  • Btk protein, mouse