What is known and objective: There is increasing evidence that epigenetics plays a major role in the pathogenesis of the idiopathic mental disorders. This article comments on the role of epigenetics in the pharmacotherapy, psychotherapy and nutritional management of these disorders.
Comment: There are two classes of epigenetic drugs undergoing trials for treating the idiopathic mental disorders: DNA methyltransferase and histone deacetylase inhibitors. These drugs may fulfil the need for newer and more effective drugs for treating these disorders. Psychotherapy could exert its therapeutic effect in idiopathic mental disorders through epigenetic mechanisms. As nutrients like folic acid and vitamin B(12) can influence an individual's epigenome, especially early in life, abnormal intakes of such agents may be involved in the pathogenesis of the idiopathic mental disorders. Hence, adequate emphasis should be given to such factors in an individual's nutrition, especially early in life. Nutrients such as L-methylfolate and S-adenosylmethionine may also be useful in nutritional therapy of these disorders.
What is new and conclusion: Epigenetics plays a key role in the pathogenesis of the idiopathic mental disorders. Due emphasis should be given to epigenetic mechanisms in the pharmacotherapy, psychotherapy and nutritional management of these disorders.
© 2012 Blackwell Publishing Ltd.