Antioxidant and antiangiogenic activities of the essential oils of Myristica fragrans and Morinda citrifolia

Asian Pac J Trop Med. 2012 Apr;5(4):294-8. doi: 10.1016/S1995-7645(12)60042-X.

Abstract

Objective: Toinvestigate the anti-angiogenic activity and antioxidant properties of Myristica fragrans (M. fragrans) (nutmeg) and Morinda citrifolia (M. citrifolia)(mengkudu) oils.

Methods: The nutmeg and megkudu essential oils were obtained by steam distillation. The antioxidant activities of both essential oils were determined by beta-carotene/linoleic acid bleaching assay and reducing power while the anti-angiogenic activity was investigated using rat aortic ring assay using various concentrations.

Results: The results showed that nutmeg oil has higher antioxidant activity than mengkudu oil. The nutmeg oil effectively inhibited the oxidation of linoleic acid with (88.68±0.1)% while the inhibition percentage of oxidation of linoleic acid of the mengkudu oil is (69.44±0.4)%. The nutmeg oil and mengkudu oil showed reducing power with an EC(50) value of 181.4 μg/mL and 3 043.0 μg/mL, respectively. The antiangiogenic activity of nutmeg oil showed significant antiangiogenic activity with IC(50) of 77.64 μg/mL comparing to mengkudu oil which exhibits IC(50) of 109.30 μg/mL.

Conclusions: Bioactive compound(s) will be isolated from the nutmeg essential oil to be developed as antiangiogenic drugs.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Analysis of Variance
  • Angiogenesis Inhibitors / pharmacology*
  • Animals
  • Antioxidants / pharmacology*
  • Aorta / drug effects
  • Dose-Response Relationship, Drug
  • Morinda*
  • Myristica*
  • Oils, Volatile / pharmacology*
  • Rats
  • Rats, Sprague-Dawley
  • Seeds

Substances

  • Angiogenesis Inhibitors
  • Antioxidants
  • Oils, Volatile