Study on serum cytokine levels in posttraumatic stress disorder patients

Asian Pac J Trop Med. 2012 Apr;5(4):323-5. doi: 10.1016/S1995-7645(12)60048-0.


Objective: To evaluate serum IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α levels in posttraumatic stress disorder (PTSD) patients.

Methods: We utilized ELISA technology to examine cytokines such as IL-2, IL-4, IL-6, IL-8, IL-10 and TNF-α in serum from 50 well-characterized individuals with a primary DSM-IV PTSD diagnosis, and 50 age- and gender-matched healthy controls. We conservatively employed a Mann-Whitney U testing.

Results: Individuals with primary PTSD had significantly elevated peripheral cytokine levels for all 6 different cytokines compared to age- and gender-matched healthy controls (all P<0.01).

Conclusions: These findings suggest that a generalized inflammatory state may be present in individuals with PTSD.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Case-Control Studies
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Humans
  • Interleukins / metabolism*
  • Male
  • Middle Aged
  • Stress Disorders, Post-Traumatic / blood*
  • Tumor Necrosis Factor-alpha / metabolism*


  • Interleukins
  • Tumor Necrosis Factor-alpha