Regulation of GATA4 transcriptional activity in cardiovascular development and disease

Curr Top Dev Biol. 2012;100:143-69. doi: 10.1016/B978-0-12-387786-4.00005-1.


Transcription factors regulate formation and function of the heart, and perturbation of transcription factor expression and regulation disrupts normal heart structure and function. Multiple mechanisms regulate the level and locus-specific activity of transcription factors, including transcription, translation, subcellular localization, posttranslational modifications, and context-dependent interactions with other transcription factors, chromatin remodeling enzymes, and epigenetic regulators. The zinc finger transcription factor GATA4 is among the best-studied cardiac transcriptional factors. This review focuses on molecular mechanisms that regulate GATA4 transcriptional activity in the cardiovascular system, providing a framework to investigate and understand the molecular regulation of cardiac gene transcription by other transcription factors.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cardiovascular System / embryology
  • Cardiovascular System / growth & development
  • Cardiovascular System / metabolism*
  • Chromatin
  • GATA4 Transcription Factor / genetics
  • GATA4 Transcription Factor / metabolism*
  • Gene Expression Regulation, Developmental*
  • Humans
  • Transcriptional Activation*


  • Chromatin
  • GATA4 Transcription Factor