Dual targeting strategies with bispecific antibodies

MAbs. Mar-Apr 2012;4(2):182-97. doi: 10.4161/mabs.4.2.19000. Epub 2012 Mar 1.

Abstract

Monoclonal antibodies are widely used for the treatment of cancer, inflammatory and infectious diseases and other disorders. Most of the marketed antibodies are monospecific and therefore capable of interacting and interfering with a single target. However, complex diseases are often multifactorial in nature, and involve redundant or synergistic action of disease mediators or upregulation of different receptors, including crosstalk between their signaling networks. Consequently, blockade of multiple, different pathological factors and pathways may result in improved therapeutic efficacy. This result can be achieved by combining different drugs, or use of the dual targeting strategies applying bispecific antibodies that have emerged as an alternative to combination therapy. This review discusses the various dual targeting strategies for which bispecific antibodies have been developed and provides an overview of the established bispecific antibody formats.

Keywords: allergic diseases; bispecific antibodies; cancer therapy; dual retargeting; dual targeting; inflammatory diseases.

Publication types

  • Review

MeSH terms

  • Animals
  • Antibodies, Bispecific* / immunology
  • Antibodies, Bispecific* / therapeutic use
  • Drug Delivery Systems*
  • Humans
  • Infections / drug therapy
  • Infections / immunology
  • Infections / pathology
  • Inflammation / drug therapy
  • Inflammation / immunology
  • Inflammation / pathology
  • Neoplasms / drug therapy
  • Neoplasms / immunology
  • Neoplasms / pathology
  • Signal Transduction / drug effects
  • Signal Transduction / immunology

Substances

  • Antibodies, Bispecific