Gold nanoparticles supported on nanoparticulate ceria as a powerful agent against intracellular oxidative stress

Small. 2012 Jun 25;8(12):1895-903. doi: 10.1002/smll.201102255. Epub 2012 Mar 27.


Ceria-supported gold nanoparticles are prepared exhibiting peroxidase activity and acting as radical traps. Au/CeO(2) shows a remarkable biocompatibility as demonstrated by measuring cellular viability, proliferation, and lack of apoptosis for two human cell lines (Hep3B and HeLa). The antioxidant activity of Au/CeO(2) against reactive oxygen species (ROS) is demonstrated by studying the cellular behavior of Hep3B and HeLa in a model of cellular oxidative stress. It is determined that Au/CeO(2) exhibits higher antioxidant activity than glutathione, the main cytosolic antioxidant compound, and its CeO(2) carrier. Overall the result presented here shows the potential of implementing well-established nanoparticulated gold catalysts with remarkable biocompatibility in cellular biology.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antioxidants / chemistry
  • Apoptosis
  • Biocompatible Materials / chemistry
  • Catalysis
  • Cell Line
  • Cell Proliferation
  • Cell Survival
  • Gold / chemistry*
  • HeLa Cells / drug effects*
  • Humans
  • Metal Nanoparticles / chemistry*
  • Nanoparticles / chemistry*
  • Nanotechnology / methods*
  • Oxidative Stress
  • Peroxidases / chemistry
  • Polymers / chemistry
  • Reactive Oxygen Species / metabolism
  • Time Factors


  • Antioxidants
  • Biocompatible Materials
  • Polymers
  • Reactive Oxygen Species
  • Gold
  • Peroxidases