Host Gene Expression Changes Correlating With anti-HIV-1 Effects in Human Subjects After Treatment With Peginterferon Alfa-2a

J Infect Dis. 2012 May 1;205(9):1443-7. doi: 10.1093/infdis/jis211. Epub 2012 Mar 26.

Abstract

We investigated whether interferon-inducible genes (IFIGs) with known anti-human immunodeficiency virus (HIV) activity in vitro were associated with in vivo virological response in HIV infection. Nine untreated HIV-1-infected volunteers were treated for 12 weeks with peginterferon alfa-2a. A subset of IFIGs (23 of 47) increased compared with baseline through 6 weeks beyond therapy, and 10 of the 23 IFIGs significantly inversely correlated (r = -0.7; P < .05) with virological response. The strength of peginterferon alfa-2a-induced IFIG response significantly correlated with declines in HIV load during treatment (r(2) = 0.87, p = .003). This study links HIV virological response to a specific IFIG subset, a potential prognostic indicator in peginterferon alfa-2a-treated patients with HIV infection.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antiviral Agents / administration & dosage*
  • Gene Expression Regulation / drug effects*
  • HIV Infections / drug therapy
  • HIV-1 / isolation & purification
  • HIV-1 / pathogenicity*
  • Host-Pathogen Interactions / genetics*
  • Humans
  • Interferon-alpha / administration & dosage*
  • Leukocytes, Mononuclear / metabolism
  • Polyethylene Glycols / administration & dosage*
  • RNA, Viral / genetics
  • RNA, Viral / isolation & purification
  • Recombinant Proteins / administration & dosage
  • Viral Load

Substances

  • Antiviral Agents
  • Interferon-alpha
  • RNA, Viral
  • Recombinant Proteins
  • Polyethylene Glycols
  • peginterferon alfa-2a