Role of forkhead transcription factors in diabetes-induced oxidative stress

Exp Diabetes Res. 2012;2012:939751. doi: 10.1155/2012/939751. Epub 2012 Jan 31.

Abstract

Diabetes is a chronic metabolic disorder, characterized by hyperglycemia resulting from insulin deficiency and/or insulin resistance. Recent evidence suggests that high levels of reactive oxygen species (ROS) and subsequent oxidative stress are key contributors in the development of diabetic complications. The FOXO family of forkhead transcription factors including FOXO1, FOXO3, FOXO4, and FOXO6 play important roles in the regulation of many cellular and biological processes and are critical regulators of cellular oxidative stress response pathways. FOXO1 transcription factors can affect a number of different tissues including liver, retina, bone, and cell types ranging from hepatocytes to microvascular endothelial cells and pericytes to osteoblasts. They are induced by oxidative stress and contribute to ROS-induced cell damage and apoptosis. In this paper, we discuss the role of FOXO transcription factors in mediating oxidative stress-induced cellular response.

Publication types

  • Research Support, N.I.H., Extramural
  • Review

MeSH terms

  • Diabetes Mellitus / metabolism*
  • Forkhead Transcription Factors / metabolism*
  • Humans
  • Liver / metabolism*
  • Oxidative Stress / physiology*
  • Reactive Oxygen Species / metabolism

Substances

  • Forkhead Transcription Factors
  • Reactive Oxygen Species