Vitamin C improves the quality of somatic cell reprogramming

Miguel A Esteban; Duanqing Pei

doi:10.1038/ng.2222

Vitamin C improves the quality of somatic cell reprogramming

Nat Genet. 2012 Mar 28;44(4):366-7. doi: 10.1038/ng.2222.

Authors

Miguel A Esteban¹, Duanqing Pei

Affiliation

¹ Stem Cell and Cancer Biology Group at the Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China. esteban@gibh.org

PMID: 22456737
DOI: 10.1038/ng.2222

Abstract

The reprogramming of somatic cells to a pluripotent state is prone to errors that could hamper the use of this technology. A new study now shows that vitamin C enhances the quality of somatic cell reprogramming in mice, highlighting the possibility that further manipulation of culture conditions could improve this technology for regenerative medicine.

Publication types

News
Comment

MeSH terms

Animals
Ascorbic Acid / pharmacology*
B-Lymphocytes / cytology*
B-Lymphocytes / metabolism*
Calcium-Binding Proteins
Genomic Imprinting*
Induced Pluripotent Stem Cells*
Intercellular Signaling Peptides and Proteins / genetics*

Substances

Calcium-Binding Proteins
Dlk1 protein, mouse
Intercellular Signaling Peptides and Proteins
Ascorbic Acid