Cyclic diarylheptanoids as inhibitors of NO production from Acer nikoense

J Nat Med. 2013 Jan;67(1):234-9. doi: 10.1007/s11418-012-0660-0. Epub 2012 Mar 29.


We prepared a series of acerogenins A and B derivatives as inhibitors of nitric oxide (NO) production in vitro. Our results suggested that an ester group at a hydroxyl at C-2 improved inhibitory effects without cytotoxicity. A benzoyl ester derivative of acerogenin C showed the most potent inhibitory activity of NO production from lipopolysaccharide-activated macrophages.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Acer / drug effects*
  • Acer / metabolism*
  • Diarylheptanoids / chemistry*
  • Diarylheptanoids / pharmacology*
  • Nitric Oxide / metabolism*


  • Diarylheptanoids
  • Nitric Oxide