The effect of vibration applied to the hand on skin sympathetic activity (SSA) in the lower limbs was studied in five healthy subjects. SSA from the right tibial nerve at the popliteal fossa, plethysmogram from the right index toe and perspiration from the sole of the right foot were measured when vibration of 100 m/s2 at 60 Hz was applied to the left palm for 1 min. The SSA response to vibration exposure differed among subjects, but every subject showed an increase in SSA from the tibial nerve when vibration was applied to the hand. Decrease in amplitude of plethysmogram from the toe was also found in all subjects. One subject displayed a remarkable increase in perspiration on the sole of the foot together with a great increase in SSA. The present findings indicated that even vibration exposure of the hand triggers sympathetic activity in the tibial nerve innervating the foot, and causes vasoconstriction of the toe and perspiration on the sole of the foot.