Serum antibodies reactive with Saccharomyces cerevisiae in inflammatory bowel disease: is IgA antibody a marker for Crohn's disease?

Int Arch Allergy Appl Immunol. 1990;92(1):9-15. doi: 10.1159/000235217.

Abstract

Sera from patients with Crohn's disease (CD) and ulcerative colitis (UC) have been evaluated for antibodies reactive with Saccharomyces cerevisiae (anti-Sacc antibodies) using an enzyme-linked immunoassay (ELISA). IgG anti-Sacc antibodies were detected in 63% (25/40) of CD patients, compared with 15% (4/27) of UC patients (p less than 0.001) and 8% (5/60) healthy adult controls (p less than 0.001). Furthermore, the prevalence of detectable IgG anti-Sacc antibodies in adult patients with coeliac disease, dermatitis herpetiformis, irritable bowel syndrome or atopic eczema was not significantly different to controls. In comparison, the prevalence of detectable IgG anti-Escherichia coli antibodies was not significantly different between CD (75%) or UC (79%) patients. More particularly, elevated levels of serum IgA anti-Sacc antibodies were detected in 17/40 CD patients, but in none of the 27 UC patients. These data confirm that serum antibodies reactive with S. cerevisiae are strongly associated with CD and further show that serum IgA anti-Sacc antibodies may be specific for this disorder.

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Antibodies, Fungal / analysis*
  • Biomarkers / blood
  • Colitis, Ulcerative / immunology*
  • Crohn Disease / immunology*
  • Female
  • Humans
  • Immunoglobulin A / analysis*
  • Immunoglobulin G / analysis
  • Male
  • Middle Aged
  • Saccharomyces cerevisiae / immunology*

Substances

  • Antibodies, Fungal
  • Biomarkers
  • Immunoglobulin A
  • Immunoglobulin G