Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics

Peter Sass; Anne Berscheid; Andrea Jansen; Marion Oedenkoven; Christiane Szekat; Axel Strittmatter; Gerhard Gottschalk; Gabriele Bierbaum

doi:10.1128/JB.06631-11

Genome sequence of Staphylococcus aureus VC40, a vancomycin- and daptomycin-resistant strain, to study the genetics of development of resistance to currently applied last-resort antibiotics

J Bacteriol. 2012 Apr;194(8):2107-8. doi: 10.1128/JB.06631-11.

Authors

Peter Sass¹, Anne Berscheid, Andrea Jansen, Marion Oedenkoven, Christiane Szekat, Axel Strittmatter, Gerhard Gottschalk, Gabriele Bierbaum

Affiliation

¹ Institute of Medical Microbiology, Immunology and Parasitology (IMMIP), University of Bonn, Bonn, Germany. psass@uni-bonn.de

Abstract

The increasing emergence of multidrug-resistant Staphylococcus aureus is a problem of global importance. Here, we report the genome of S. aureus VC40, which is resistant to the last-resort antibiotics vancomycin and daptomycin. Its genome sequence will allow insights into the mechanisms that convey full resistance to these compounds.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anti-Bacterial Agents / pharmacology
Base Sequence
Daptomycin / pharmacology*
Drug Resistance, Multiple, Bacterial / genetics*
Gene Expression Regulation, Bacterial / drug effects
Genome, Bacterial
Molecular Sequence Data
Staphylococcus aureus / drug effects*
Staphylococcus aureus / genetics*
Vancomycin / pharmacology*

Substances

Anti-Bacterial Agents
Vancomycin
Daptomycin

Associated data

GENBANK/CP003033