Antiviral activity of Inonotus obliquus fungus extract towards infection caused by hepatitis C virus in cell cultures

Bull Exp Biol Med. 2011 Sep;151(5):612-4. doi: 10.1007/s10517-011-1395-8.


Fractions of Inonotus obliquus fungus water extract exhibited a virucidal effect towards hepatitis C virus: it 100-fold reduced its infective properties within 10 min. The antiviral effects of fungus extracts manifested after preventive (24 h before infection) and therapeutic use (during infection of porcine embryo kidney cells). Moreover, the data indicate that the birch fungus extracts inhibit production of infective virus by porcine embryo kidney cells.

MeSH terms

  • Animals
  • Antiviral Agents / isolation & purification
  • Antiviral Agents / pharmacology*
  • Basidiomycota / chemistry*
  • Cells, Cultured
  • Female
  • Hepacivirus / drug effects*
  • Hepatitis C, Chronic / virology
  • Humans
  • Solvents / chemistry
  • Swine
  • Virion / drug effects
  • Water / chemistry


  • Antiviral Agents
  • Solvents
  • Water