A noninvasive method of examination of the hemostasis system

Bull Exp Biol Med. 2011 Sep;151(5):655-7. doi: 10.1007/s10517-011-1407-8.


We propose a noninvasive method of in vivo examination the hemostasis system based on speckle pattern analysis of coherent light scattering from the skin. We compared the results of measuring basic blood coagulation parameters by conventional invasive and noninvasive methods. A strict correlation was found between the results of measurement of soluble fibrin monomer complexes, international normalized ratio (INR), prothrombin index, and protein C content. The noninvasive method of examination of the hemostatic system enable rough evaluation of the intensity of the intravascular coagulation and correction of the dose of indirect anticoagulants maintaining desired values of INR or prothrombin index.

MeSH terms

  • Blood Chemical Analysis / methods*
  • Blood Viscosity
  • Fibrin / metabolism
  • Hemostasis*
  • Humans
  • International Normalized Ratio
  • Light
  • Protein C / metabolism
  • Prothrombin / metabolism
  • Scattering, Radiation


  • Protein C
  • Prothrombin
  • Fibrin