Methicillin-resistant Staphylococcus aureus colonization among women admitted for preterm delivery

Am J Obstet Gynecol. 2012 Apr;206(4):329.e1-5. doi: 10.1016/j.ajog.2012.01.038. Epub 2012 Feb 1.


Objective: Methicillin-resistant Staphylococcus aureus infection is associated with morbidity in the neonatal intensive care unit. The purpose of this study was to determine the relationship between preterm maternal methicillin-resistant S aureus colonization and subsequent colonization and infection in premature neonates.

Study design: We conducted a prospective cohort study of 422 women admitted for preterm delivery. Methicillin-resistant S aureus cultures were collected from mothers and their neonates admitted to neonatal intensive care unit. We determined the proportion of women and neonates colonized with methicillin-resistant S aureus and examined possible factors associated with colonization and infection.

Results: Fifteen of 422 (3.6%) women were found to be colonized with methicillin-resistant S aureus. Thirteen of 212 (6.1%) neonates admitted to neonatal intensive care unit were methicillin-resistant S aureus colonized and 3 of 13 (23.1%) developed a methicillin-resistant S aureus infection. We identified 1 methicillin-resistant S aureus colonized maternal-neonatal pair. The infant became methicillin-resistant S aureus positive 30 days after admission and did not develop a methicillin-resistant S aureus infection.

Conclusion: These findings suggest that maternal methicillin-resistant S aureus colonization is not a significant risk factor for vertical transmission of neonatal methicillin-resistant S aureus colonization.

MeSH terms

  • Adult
  • Female
  • Gestational Age
  • Humans
  • Infant, Newborn
  • Infant, Premature
  • Infectious Disease Transmission, Vertical / statistics & numerical data
  • Intensive Care Units, Neonatal / statistics & numerical data
  • Male
  • Methicillin-Resistant Staphylococcus aureus / isolation & purification*
  • Obstetric Labor, Premature / microbiology*
  • Pregnancy
  • Pregnancy Complications, Infectious / diagnosis
  • Pregnancy Complications, Infectious / epidemiology*
  • Pregnancy Complications, Infectious / microbiology
  • Prospective Studies
  • Staphylococcal Infections / diagnosis
  • Staphylococcal Infections / epidemiology*
  • Staphylococcal Infections / transmission
  • Young Adult