A molecular doorstop ensures a trickle through translational repression

Cell. 2012 Mar 30;149(1):13-5. doi: 10.1016/j.cell.2012.03.010.

Abstract

Switching mRNA translation off and on is central to regulated gene expression, but what mechanisms moderate the extent of switch-off? Yao et al. describe how basal expression from interferon-gamma-induced transcripts is maintained during mRNA-specific translational repression. This antagonistic mechanism utilizes a truncated RNA-binding factor generated by a unique alternative polyadenylation event.

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