Insights into the mechanism of electron transfer and sodium translocation of the Na(+)-pumping NADH:quinone oxidoreductase

Biochim Biophys Acta. 2012 Oct;1817(10):1823-32. doi: 10.1016/j.bbabio.2012.03.017. Epub 2012 Mar 23.


Na(+)-NQR is a unique energy-transducing complex, widely distributed among marine and pathogenic bacteria. It converts the energy from the oxidation of NADH and the reduction of quinone into an electrochemical Na(+)-gradient that can provide energy for the cell. Na(+)-NQR is not homologous to any other respiratory protein but is closely related to the RNF complex. In this review we propose that sodium pumping in Na(+)-NQR is coupled to the redox reactions by a novel mechanism, which operates at multiple sites, is indirect and mediated by conformational changes of the protein. This article is part of a Special Issue entitled: 17th European Bioenergetics Conference (EBEC 2012).

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Catalytic Domain
  • NADH, NADPH Oxidoreductases* / chemistry
  • NADH, NADPH Oxidoreductases* / metabolism
  • NADP* / chemistry
  • NADP* / metabolism
  • Oxidation-Reduction
  • Sodium-Potassium-Exchanging ATPase* / chemistry
  • Sodium-Potassium-Exchanging ATPase* / metabolism


  • NADP
  • NADH, NADPH Oxidoreductases
  • Sodium-Potassium-Exchanging ATPase