Sector laser photocoagulation for the prevention of macular edema after plaque radiotherapy for uveal melanoma: a pilot study

Retina. 2012 Sep;32(8):1601-7. doi: 10.1097/IAE.0b013e3182437e70.

Abstract

Objective: To investigate the role of sector laser photocoagulation for prevention of macular edema after plaque radiotherapy for uveal melanoma.

Methods: Noncomparative, pilot interventional case series. The main outcome measure was optical coherence tomography-evident macular edema.

Results: A total of 29 patients had sector laser photocoagulation (sector panretinal photocoagulation) and sub-Tenon triamcinolone injection. The median tumor thickness and base was 3.3 mm and 10.0 mm. The median radiation dose and rate to the macula was 2,944 cGy and 31.0 cGy/hour. At the 12-month and 24-months follow-up, cystoid macular edema was found in 17% and 24% of the sector panretinal photocoagulation group. There were no major side effects registered.

Conclusion: Sector panretinal photocoagulation in combination with sub-Tenon triamcinolone appears to show potential as a safe and beneficial intervention for the prevention of macular edema after plaque radiotherapy for uveal melanoma in this series.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Brachytherapy / adverse effects*
  • Combined Modality Therapy
  • Female
  • Follow-Up Studies
  • Glucocorticoids / administration & dosage
  • Humans
  • Laser Coagulation*
  • Macula Lutea / radiation effects*
  • Macular Edema / diagnosis
  • Macular Edema / etiology
  • Macular Edema / prevention & control*
  • Male
  • Melanoma / radiotherapy*
  • Middle Aged
  • Pilot Projects
  • Radiation Injuries / diagnosis
  • Radiation Injuries / etiology
  • Radiation Injuries / prevention & control*
  • Radiotherapy Dosage
  • Tomography, Optical Coherence
  • Triamcinolone Acetonide / administration & dosage
  • Uveal Neoplasms / radiotherapy*

Substances

  • Glucocorticoids
  • Triamcinolone Acetonide