Inhibitory activity of Aloe vera gel on some clinically isolated cariogenic and periodontopathic bacteria

J Oral Sci. 2012 Mar;54(1):15-21. doi: 10.2334/josnusd.54.15.


Aloe vera is a medicinal plant with anti-inflammatory, antimicrobial, antidiabetic and immune-boosting properties. In the present study we investigated the inhibitory activities of Aloe vera gel on some cariogenic (Streptococcus mutans), periodontopathic (Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis) and an opportunistic periodontopathogen (Bacteroides fragilis) isolated from patients with dental caries and periodontal diseases. Twenty isolates of each of these bacteria were investigated for their sensitivity to Aloe vera gel using the disk diffusion and microdilution methods. S. mutans was the species most sensitive to Aloe vera gel with a MIC of 12.5 µg/ml, while A. actinomycetemcomitans, P. gingivalis, and B. fragilis were less sensitive, with a MIC of 25-50 µg/ml (P < 0.01). Based on our present findings it is concluded that Aloe vera gel at optimum concentration could be used as an antiseptic for prevention of dental caries and periodontal diseases.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aggregatibacter actinomycetemcomitans / drug effects*
  • Aloe* / chemistry
  • Bacteroides / drug effects*
  • Colony Count, Microbial
  • Dental Caries / microbiology
  • Emodin / analogs & derivatives
  • Emodin / pharmacology
  • Gels
  • Humans
  • Microbial Sensitivity Tests
  • Periodontal Diseases / microbiology
  • Plant Extracts / pharmacology*
  • Plant Leaves
  • Porphyromonas gingivalis / drug effects*
  • Streptococcus mutans / drug effects*


  • Gels
  • Plant Extracts
  • Emodin
  • alloin