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. 2012 Feb;5(2):42-8.

Effect of 635nm Low-level Laser Therapy on Upper Arm Circumference Reduction: A Double-blind, Randomized, Sham-controlled Trial

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Effect of 635nm Low-level Laser Therapy on Upper Arm Circumference Reduction: A Double-blind, Randomized, Sham-controlled Trial

Mark S Nestor et al. J Clin Aesthet Dermatol. .
Free PMC article

Abstract

Objective: To assess the safety and efficacy of low-level laser therapy as a noninvasive method for reducing upper arm circumference.

Design: Randomized, double-blind study whereby healthy subjects (N=40) with a body mass index of 20 to 35kg/m(2) received three 20-minute low-level laser therapy (N=20) or sham treatments (N=20) each week for two weeks.

Measurements: Upper arm circumference was measured after three and six treatments and two weeks post-treatment. Primary success criterion was the proportion of subjects achieving a combined reduction in arm circumference of ≥1.25cm measured at three equally spaced points between the elbow and the shoulder. Secondary outcomes included total measurement change at each time point and subjective satisfaction ratings.

Results: After six treatments, the low-level laser therapy group showed a combined reduction in arm circumference of 3.7cm versus 0.2cm in the sham treatment group (p<0.0001). Significantly more subjects in the low-level laser therapy group (N=12; 60%) achieved ≥1.5cm total decrease in upper arm circumference versus sham-treated subjects (N=0; 0%) (p<0.0005). Low-level laser therapy treatment resulted in a combined reduction in arm circumference of 2.2cm after three treatments and 3.7cm after six treatments (for each, p<0.0001) indicating a progressive and cumulative treatment effect. Body mass index remained unchanged for all subjects. A significantly greater number of subjects in the low-level laser therapy treatment group were satisfied with their results (p<0.05), believed their upper arm appearance improved (p<0.0005), and indicated the results exceeded expectations (p<0.05). The treatments were painless and no adverse events were reported.

Conclusion: Noninvasive low-level laser therapy is safe, painless, and effective in reducing upper arm circumference and is associated with a high degree of subject satisfaction.

Conflict of interest statement

DISCLOSURE:This study was sponsored by a research grant from Erchonia Corporation, McKinney, Texas. Dr. Nestor has received honoraria as a speaker for Erchonia Corporation as well as from Zeltiq Aesthetics, Inc., and Human Med Inc. Drs. Zarraga and Park report no relevant conflicts of interest.

Figures

Figure 1
Figure 1
Among subjects treated with low-level laser therapy, the mean decrease in upper arm circumference was significantly greater than sham-treated subjects at Week 1 (3 treatments), Week 2 (6 treatments), and Week 4 (2 weeks post-treatment). *=p<0.0001, Fischer's exact test.
Figure 2
Figure 2
Significantly more subjects in the low-level laser therapygroup (LLLT) were satisfied with their results. None of the LLLT-treated subjects indicated any level of dissatisfaction. *=p<0.05, Fischer's exact test.
Figure 3
Figure 3
Significantly more subjects in the low-level laser therapy group perceived an improvement in the appearance of their upperarms. *=p<0.005, Fischer's exact test.
Figure 4
Figure 4
Significantly more subjects in the low-level laser therapy (LLLT) group believed the results they achieved following the LLLT procedure exceeded their expectations. *=p<0.05, Fischer's exact test.

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