Fecal transplant against relapsing Clostridium difficile-associated diarrhea in 32 patients

Scand J Gastroenterol. 2012 May;47(5):548-52. doi: 10.3109/00365521.2012.672587. Epub 2012 Apr 2.

Abstract

Clostridium difficile-associated disease (CDAD) with frequent watery stools, sometimes with painful bowel movements, fever and sickness, is probably the major known cause of antibiotic-associated diarrhea and colitis, most probably depending on a disruption of the normal intestinal balance in the microbiome. In this study, we have inoculated a mixture of fecal microbes--as an enema--originating from a healthy Scandinavian middle-aged donor, regularly re-cultivated under strict anaerobic conditions for more than 10 years, to 32 patients. Twenty-two patients (69%) were durably cured. In those patients receiving the transplant by colonoscopy, four out of five were cured. To the best of our knowledge, this is the first time a fecal culture of microbes has retained the possibility for years to cure a substantial number of patients with CDAD.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Bacterial Agents / adverse effects
  • Anti-Bacterial Agents / therapeutic use
  • Bacteria, Anaerobic
  • Biological Therapy
  • Clostridioides difficile*
  • Clostridium Infections / complications
  • Clostridium Infections / drug therapy
  • Colon / microbiology
  • Colonoscopy
  • Diarrhea / microbiology*
  • Diarrhea / therapy*
  • Enema
  • Feces / microbiology*
  • Female
  • Humans
  • Male
  • Metagenome / drug effects
  • Middle Aged
  • Rectum / microbiology
  • Recurrence

Substances

  • Anti-Bacterial Agents