Child development and molecular genetics: 14 years later

Child Dev. Jan-Feb 2013;84(1):104-20. doi: 10.1111/j.1467-8624.2012.01757.x. Epub 2012 Mar 30.


Fourteen years ago, the first article on molecular genetics was published in this journal: Child Development, Molecular Genetics, and What to Do With Genes Once They Are Found (R. Plomin & M. Rutter, 1998). The goal of the article was to outline what developmentalists can do with genes once they are found. These new directions for developmental research are still relevant today. The problem lies with the phrase "once they are found": It has been much more difficult than expected to identify genes responsible for the heritability of complex traits and common disorders, the so-called missing heritability problem. The present article considers reasons for the missing heritability problem and possible solutions.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Child
  • Child Development / physiology*
  • Developmental Disabilities / genetics*
  • Epigenesis, Genetic
  • Epistasis, Genetic / genetics
  • Follow-Up Studies
  • Genes / genetics*
  • Genetic Predisposition to Disease / genetics
  • Genome, Human / genetics*
  • Genome-Wide Association Study
  • Genomic Structural Variation / genetics
  • Humans
  • Oligonucleotide Array Sequence Analysis / methods