Clinical pharmacology, uses, and adverse reactions of iodinated contrast agents: a primer for the non-radiologist

Mayo Clin Proc. 2012 Apr;87(4):390-402. doi: 10.1016/j.mayocp.2012.01.012.


Iodinated contrast agents have been in use since the 1950s to facilitate radiographic imaging modalities. Physicians in almost all specialties will either administer these agents or care for patients who have received these drugs. Different iodinated contrast agents vary greatly in their properties, uses, and toxic effects. Therefore, clinicians should be at least superficially familiar with the clinical pharmacology, administration, risks, and adverse effects associated with iodinated contrast agents. This primer offers the non-radiologist physician the opportunity to gain insight into the use of this class of drugs.

Publication types

  • Review

MeSH terms

  • Contrast Media / adverse effects
  • Contrast Media / pharmacology*
  • Drug Hypersensitivity*
  • Humans
  • Injections, Intra-Arterial
  • Injections, Intravenous
  • Iodine Compounds* / adverse effects
  • Iodine Compounds* / pharmacology


  • Contrast Media
  • Iodine Compounds