Twists and turns of invasion

Nat Cell Biol. 2012 Apr 2;14(4):337-9. doi: 10.1038/ncb2477.


The transcription factor Twist1 is overexpressed in tumours and can induce the epithelial-mesenchymal transition, resulting in increased invasiveness. Twist1 is now shown to regulate cancer cell migration and invasion in three-dimensional environments by activating the RAC1 GTPase through suppression of a let-7 microRNA family member.

Publication types

  • News
  • Comment

MeSH terms

  • Cell Movement*
  • Humans
  • Neoplasms / metabolism*
  • Neoplasms / pathology*
  • Nuclear Proteins / metabolism*
  • Twist-Related Protein 1 / metabolism*
  • rac1 GTP-Binding Protein / metabolism*


  • Nuclear Proteins
  • RAC1 protein, human
  • TWIST1 protein, human
  • Twist-Related Protein 1
  • rac1 GTP-Binding Protein