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. 2012 May 21;30(24):3572-9.
doi: 10.1016/j.vaccine.2012.03.051. Epub 2012 Mar 31.

Age of Recipient and Number of Doses Differentially Impact Human B and T Cell Immune Memory Responses to HPV Vaccination

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Age of Recipient and Number of Doses Differentially Impact Human B and T Cell Immune Memory Responses to HPV Vaccination

Kinga K Smolen et al. Vaccine. .

Abstract

Vaccination is one of the most effective medical interventions. However, optimization of existing as well as design of new vaccines is still mostly conducted empirically; a rational approach to vaccine design is largely prohibited by the lack of insight into the relevant mechanisms underlying immune-mediated protection. To delineate the impact of variables on immune memory formation following vaccination, we took advantage of a trial assessing the role of the age of the recipient and the number of administered doses of the quadrivalent HPV vaccine in a well-characterized longitudinal cohort of girls and young women. We found that age of the recipient and the number of doses administered differentially impact the development of B and T cell memory. Specifically, age of the recipient significantly impacted generation of HPV 18-specific B cell memory, while the number of vaccine doses displayed a significant effect on the development of HPV-specific T cell memory. Our data indicate that rational design of vaccines has to be tailored according to the desired induction of B and/or T cell memory.

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