Should more patients continue aspirin therapy perioperatively?: clinical impact of aspirin withdrawal syndrome

Ann Surg. 2012 May;255(5):811-9. doi: 10.1097/SLA.0b013e318250504e.


Objective: To provide an evidence-based focused review of aspirin use in the perioperative period along with an in-depth discussion of the considerations and risks associated with its preoperative withdrawal.

Background: For patients with established cardiovascular disease, taking aspirin is considered a critical therapy. The cessation of aspirin can cause a platelet rebound phenomenon and prothrombotic state leading to major adverse cardiovascular events. Despite the risks of aspirin withdrawal, which are exacerbated during the perioperative period, standard practice has been to stop aspirin before elective surgery for fear of excessive bleeding. Mounting evidence suggests that this practice should be abandoned.

Methods: We performed a PubMed and Medline literature search using the keywords aspirin, withdrawal, and perioperative. We manually reviewed relevant citations for inclusion.

Results/conclusions: Clinicians should employ a patient-specific strategy for perioperative aspirin management that weighs the risks of stopping aspirin with those associated with its continuation. Most patients, especially those taking aspirin for secondary cardiovascular prevention, should have their aspirin continued throughout the perioperative period. When aspirin is held preoperatively, the aspirin withdrawal syndrome may significantly increase the risk of a major thromboembolic complication. For many operative procedures, the risk of perioperative bleeding while continuing aspirin is minimal, as compared with the concomitant thromboembolic risks associated with aspirin withdrawal. Those cases where aspirin should be stopped include patients undergoing intracranial, middle ear, posterior eye, intramedullary spine, and possibly transurethral prostatectomy surgery.

Publication types

  • Review

MeSH terms

  • Aspirin / pharmacology
  • Aspirin / therapeutic use*
  • Blood Platelets / drug effects
  • Cardiac Surgical Procedures
  • Cardiovascular Diseases / prevention & control
  • Hemorrhage / etiology*
  • Humans
  • Mohs Surgery
  • Orthopedic Procedures
  • Perioperative Care*
  • Perioperative Period
  • Platelet Aggregation Inhibitors / pharmacology
  • Platelet Aggregation Inhibitors / therapeutic use*
  • Thrombosis / prevention & control
  • Urologic Surgical Procedures
  • Vascular Surgical Procedures


  • Platelet Aggregation Inhibitors
  • Aspirin