Tea tree oil as a novel antipsoriasis weapon

Skin Pharmacol Physiol. 2012;25(3):162-3. doi: 10.1159/000337936. Epub 2012 Apr 3.


Psoriasis is a clinical skin disease that is characterized by erythematous scaling plaques and involves the extensor site of the extremities, the scalp and other surfaces of the skin. Tea tree oil (TTO) is considered an essential oil, obtained by steam distillation of the leaves and terminal branchlets of Melaleuca alternifolia. Notably,terpinen-4-ol, the major TTO constituent, has been found to have potent anti-inflammatory properties. It is suggested that terpinen-4-ol may be a novel potential agent against psoriasis. This article draws attention to the antipsoriatic effect of TTO and provides a theoretical molecular approach.

Publication types

  • Letter

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / adverse effects
  • Anti-Inflammatory Agents / therapeutic use*
  • Dermatologic Agents / adverse effects
  • Dermatologic Agents / therapeutic use*
  • Humans
  • Inflammation Mediators / metabolism
  • Psoriasis / drug therapy*
  • Psoriasis / immunology
  • Psoriasis / pathology
  • Skin / blood supply
  • Skin / drug effects*
  • Skin / immunology
  • Skin / pathology
  • Tea Tree Oil / adverse effects
  • Tea Tree Oil / therapeutic use*
  • Vasodilation / drug effects


  • Anti-Inflammatory Agents
  • Dermatologic Agents
  • Inflammation Mediators
  • Tea Tree Oil