Lactate-induced IL-8 pathway in endothelial cells--letter

Cancer Res. 2012 Apr 1;72(7):1901-2; author reply 1903-4. doi: 10.1158/0008-5472.CAN-11-1540.

Abstract

Végran and colleagues proposed a model in which the lactate released from tumor cells through MCT4 would be taken up by endothelial cells via the MCT1 transporter and stimulate angiogenesis, using human umbilical vein endothelial cells (HUVECs) as model of tumor endothelial cells. By analyzing a total of 505 cases of human tumor samples immunostained for MCT1, we do not confirm plasma membrane expression of MCT1 in the endothelial cells of tumor-associated vessels.

Publication types

  • Letter
  • Comment

MeSH terms

  • Breast Neoplasms / blood supply*
  • Colorectal Neoplasms / blood supply*
  • Humans
  • Interleukin-8 / metabolism*
  • Lactic Acid / pharmacokinetics*
  • Monocarboxylic Acid Transporters / metabolism*
  • NF-kappa B / metabolism*
  • Symporters / metabolism*

Substances

  • Interleukin-8
  • Monocarboxylic Acid Transporters
  • NF-kappa B
  • Symporters
  • Lactic Acid