This site needs JavaScript to work properly. Please enable it to take advantage of the complete set of features!

Skip to main page content

Email citation

Add to Collections

Your saved search

Name of saved search:

Search terms:

Test search terms

Would you like email updates of new search results?

Yes
No

Email: (change)

Frequency:

Which day?

Which day?

Report format:

Send at most:

Send even when there aren't any new results

Optional text in email:

Your RSS Feed

. 2012 Mar;12(2):66-8.

doi: 10.5698/1535-7511-12.2.66.

Tales of a dirty drug: carbenoxolone, gap junctions, and seizures

Barry W Connors

PMID: 22473546
PMCID: PMC3316363
DOI: 10.5698/1535-7511-12.2.66

Tales of a dirty drug: carbenoxolone, gap junctions, and seizures

Barry W Connors. Epilepsy Curr. 2012 Mar.

. 2012 Mar;12(2):66-8.

doi: 10.5698/1535-7511-12.2.66.

Author

Barry W Connors

PMID: 22473546
PMCID: PMC3316363
DOI: 10.5698/1535-7511-12.2.66

No abstract available

PubMed Disclaimer

Similar articles

Involvement of gap junctions in the manifestation and control of the duration of seizures in rats in vivo.
Gajda Z, Gyengési E, Hermesz E, Ali KS, Szente M. Gajda Z, et al. Epilepsia. 2003 Dec;44(12):1596-600. doi: 10.1111/j.0013-9580.2003.25803.x. Epilepsia. 2003. PMID: 14636335
Thalamic modulation of cingulate seizure activity via the regulation of gap junctions in mice thalamocingulate slice.
Chang WP, Wu JJ, Shyu BC. Chang WP, et al. PLoS One. 2013 May 14;8(5):e62952. doi: 10.1371/journal.pone.0062952. Print 2013. PLoS One. 2013. PMID: 23690968 Free PMC article.
Decreased fast ripples in the hippocampus of rats with spontaneous recurrent seizures treated with carbenoxolone and quinine.
Ventura-Mejía C, Medina-Ceja L. Ventura-Mejía C, et al. Biomed Res Int. 2014;2014:282490. doi: 10.1155/2014/282490. Epub 2014 Sep 3. Biomed Res Int. 2014. PMID: 25276773 Free PMC article.
A possible role for gap junctions in generation of very fast EEG oscillations preceding the onset of, and perhaps initiating, seizures.
Traub RD, Whittington MA, Buhl EH, LeBeau FE, Bibbig A, Boyd S, Cross H, Baldeweg T. Traub RD, et al. Epilepsia. 2001 Feb;42(2):153-70. doi: 10.1046/j.1528-1157.2001.26900.x. Epilepsia. 2001. PMID: 11240585 Review.
Axonal gap junctions between principal neurons: a novel source of network oscillations, and perhaps epileptogenesis.
Traub RD, Draguhn A, Whittington MA, Baldeweg T, Bibbig A, Buhl EH, Schmitz D. Traub RD, et al. Rev Neurosci. 2002;13(1):1-30. doi: 10.1515/revneuro.2002.13.1.1. Rev Neurosci. 2002. PMID: 12013024 Review.

See all similar articles

Cited by

Glucocorticoid therapy and ocular hypertension.
Dibas A, Yorio T. Dibas A, et al. Eur J Pharmacol. 2016 Sep 15;787:57-71. doi: 10.1016/j.ejphar.2016.06.018. Epub 2016 Jul 5. Eur J Pharmacol. 2016. PMID: 27388141 Free PMC article. Review.
Calcium oscillations coordinate feather mesenchymal cell movement by SHH dependent modulation of gap junction networks.
Li A, Cho JH, Reid B, Tseng CC, He L, Tan P, Yeh CY, Wu P, Li Y, Widelitz RB, Zhou Y, Zhao M, Chow RH, Chuong CM. Li A, et al. Nat Commun. 2018 Dec 18;9(1):5377. doi: 10.1038/s41467-018-07661-5. Nat Commun. 2018. PMID: 30560870 Free PMC article.
The Display of Single-Domain Antibodies on the Surfaces of Connectosomes Enables Gap Junction-Mediated Drug Delivery to Specific Cell Populations.
Gadok AK, Zhao C, Meriwether AI, Ferrati S, Rowley TG, Zoldan J, Smyth HDC, Stachowiak JC. Gadok AK, et al. Biochemistry. 2018 Jan 9;57(1):81-90. doi: 10.1021/acs.biochem.7b00688. Epub 2017 Sep 1. Biochemistry. 2018. PMID: 28829120 Free PMC article.
Neural Interactions in Developing Rhythmogenic Spinal Networks: Insights From Computational Modeling.
Shevtsova NA, Ha NT, Rybak IA, Dougherty KJ. Shevtsova NA, et al. Front Neural Circuits. 2020 Dec 23;14:614615. doi: 10.3389/fncir.2020.614615. eCollection 2020. Front Neural Circuits. 2020. PMID: 33424558 Free PMC article.
The Anti-Epileptic Effects of Carbenoxolone In Vitro and In Vivo.
Volnova A, Tsytsarev V, Ganina O, Vélez-Crespo GE, Alves JM, Ignashchenkova A, Inyushin M. Volnova A, et al. Int J Mol Sci. 2022 Jan 8;23(2):663. doi: 10.3390/ijms23020663. Int J Mol Sci. 2022. PMID: 35054848 Free PMC article.

See all "Cited by" articles

References

1. Juszczak GR, Swiergiel AH. Properties of gap junction blockers and their behavioural, cognitive and electrophysiological effects: Animal and human studies. Prog Neuropsychopharmacol Biol Psychiatry. 2009;33:181–198. - PubMed
1. Rozental R, Srinivas M, Spray DC. How to close a gap junction channel: Efficacies and potencies of uncoupling agents. Methods Mol Biol. 2001;154:447–476. - PubMed
1. Connors BW, Long MA. Electrical synapses in the mammalian brain. Annu Rev Neurosci. 2004;27:393–418. - PubMed
1. Bennett MV, Pereda A. Pyramid power: Principal cells of the hippocampus unite! Brain Cell Biol. 2006;35:5–11. - PubMed
1. Carlen PL, Skinner F, Zhang L, Naus C, Kushnir M, Perez Velazquez JL. The role of gap junctions in seizures. Brain Res Brain Res Rev. 2000;32:235–241. - PubMed

LinkOut - more resources

Full Text Sources
Miscellaneous
- NCI CPTAC Assay Portal