HIF-1α binding to the Epac1 promoter recruits hematopoietic stem cells to the ischemic brain following stroke

J Mol Cell Biol. 2012 Jun;4(3):184-7. doi: 10.1093/jmcb/mjs009. Epub 2012 Apr 3.
No abstract available

Publication types

  • Letter
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Binding Sites
  • Brain / metabolism*
  • Brain / pathology
  • Brain Ischemia / complications
  • Brain Ischemia / metabolism*
  • Brain Ischemia / pathology
  • Cells, Cultured
  • Guanine Nucleotide Exchange Factors / genetics*
  • Guanine Nucleotide Exchange Factors / metabolism
  • Hematopoietic Stem Cells / metabolism
  • Hematopoietic Stem Cells / pathology*
  • Humans
  • Hypoxia-Inducible Factor 1, alpha Subunit / genetics
  • Hypoxia-Inducible Factor 1, alpha Subunit / metabolism*
  • Mice
  • Promoter Regions, Genetic*
  • Rats
  • Stroke / etiology
  • Stroke / metabolism*
  • Stroke / pathology

Substances

  • Guanine Nucleotide Exchange Factors
  • Hypoxia-Inducible Factor 1, alpha Subunit
  • RAPGEF3 protein, human