Skip to main page content
Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
, 4, 12

High Plasma Uric Acid Concentration: Causes and Consequences

Affiliations

High Plasma Uric Acid Concentration: Causes and Consequences

Erick Prado de Oliveira et al. Diabetol Metab Syndr.

Abstract

High plasma uric acid (UA) is a precipitating factor for gout and renal calculi as well as a strong risk factor for Metabolic Syndrome and cardiovascular disease. The main causes for higher plasma UA are either lower excretion, higher synthesis or both. Higher waist circumference and the BMI are associated with higher insulin resistance and leptin production, and both reduce uric acid excretion. The synthesis of fatty acids (tryglicerides) in the liver is associated with the de novo synthesis of purine, accelerating UA production. The role played by diet on hyperuricemia has not yet been fully clarified, but high intake of fructose-rich industrialized food and high alcohol intake (particularly beer) seem to influence uricemia. It is not known whether UA would be a causal factor or an antioxidant protective response. Most authors do not consider the UA as a risk factor, but presenting antioxidant function. UA contributes to > 50% of the antioxidant capacity of the blood. There is still no consensus if UA is a protective or a risk factor, however, it seems that acute elevation is a protective factor, whereas chronic elevation a risk for disease.

Figures

Figure 1
Figure 1
Determinants of hyperuricemia. UA = Uric Acid, BMI = Body Mass Index, TG = triglycerides.

Similar articles

See all similar articles

Cited by 74 articles

See all "Cited by" articles

References

    1. Kim SY, Guevara JP, Kim KM, Choi HK, Heitjan DF, Albert DA. Hyperuricemia and risk of stroke: a systematic review and meta-analysis. Arthritis Rheum. 2009;61:885–892. doi: 10.1002/art.24612. - DOI - PMC - PubMed
    1. Richette P, Bardin T. Gout Lancet. 2010. pp. 318–328. - PubMed
    1. Roddy E, Doherty M. Epidemiology of gout. Arthritis Res Ther. 2010;12:223. doi: 10.1186/ar3199. - DOI - PMC - PubMed
    1. Ruggiero C, Cherubini A, Ble A, Bos AJ, Maggio M, Dixit VD, Lauretani F, Bandinelli S, Senin U, Ferrucci L. Uric acid and inflammatory markers. Eur Heart J. 2006;27:1174–1181. - PMC - PubMed
    1. Chen JH, Chuang SY, Chen HJ, Yeh WT, Pan WH. Serum uric acid level as an independent risk factor for all-cause, cardiovascular, and ischemic stroke mortality: a Chinese cohort study. Arthritis Rheum. 2009;61:225–232. doi: 10.1002/art.24164. - DOI - PubMed

LinkOut - more resources

Feedback