Effect of time period after boric acid injection on 10B absorption in different regions of adult male rat's brain

Appl Radiat Isot. 2012 Jun;70(6):1010-3. doi: 10.1016/j.apradiso.2012.03.012. Epub 2012 Mar 21.

Abstract

Distribution of (10)B in different regions of rat normal brain was studied. Two groups were chosen as control and trial. Trial group received 2 ml of neutral boron compound. 2, 4 and 6 h after the injection brain removed, coronal sections of forebrain, midbrain and hindbrain were sandwiched between two pieces of polycarbonate. Autoradiography plots of (10)B distribution showed significant differences in three regions with the highest (10)B concentration in the forebrain during 4 h after injection.

Publication types

  • Controlled Clinical Trial
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Absorption
  • Animals
  • Boron / administration & dosage
  • Boron / pharmacokinetics*
  • Boron Neutron Capture Therapy / methods*
  • Brain / metabolism*
  • Injections
  • Isotopes / administration & dosage
  • Isotopes / pharmacokinetics
  • Male
  • Radiometry
  • Rats
  • Rats, Wistar
  • Tissue Distribution

Substances

  • Isotopes
  • Boron