This article describes the history of the Pediatric Pharmacy Advocacy Group (PPAG). From its humble beginning in 1979, to its formation as the Pediatric Directors of Pediatric Hospitals in 1985, through its time as the Pediatric Pharmacy Administrative Group and through its evolution into the PPAG. The organization was established and continues to be dedicated to improving medication therapy use in children. Its sole purpose is to promote safe and effective medication use in children through communication, education, and research. After three decades, PPAG has established itself as the preeminent pediatric pharmacy organization. Its annual conference has grown over the years to become the best educational and networking meeting for pediatric pharmacists worldwide.