IFITM Proteins Restrict Antibody-Dependent Enhancement of Dengue Virus Infection

PLoS One. 2012;7(3):e34508. doi: 10.1371/journal.pone.0034508. Epub 2012 Mar 30.

Abstract

Interferon-inducible transmembrane (IFITM) proteins restrict the entry processes of several pathogenic viruses, including the flaviviruses West Nile virus and dengue virus (DENV). DENV infects cells directly or via antibody-dependent enhancement (ADE) in Fc-receptor-bearing cells, a process thought to contribute to severe disease in a secondary infection. Here we investigated whether ADE-mediated DENV infection bypasses IFITM-mediated restriction or whether IFITM proteins can be protective in a secondary infection. We observed that IFITM proteins restricted ADE-mediated and direct infection with comparable efficiencies in a myelogenous leukemia cell line. Our data suggest that IFITM proteins can contribute to control of secondary DENV infections.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Animals
  • Antibody-Dependent Enhancement*
  • Cell Line
  • Cell Line, Tumor
  • Dengue / immunology*
  • Dengue / virology
  • Dengue Virus / immunology*
  • Humans
  • Interferons / immunology*
  • Membrane Proteins / immunology*
  • Mice

Substances

  • Membrane Proteins
  • Interferons