Structural and functional maturation of distal femoral cartilage and bone during postnatal development and growth in humans and mice

Orthop Clin North Am. 2012 Apr;43(2):173-85, v. doi: 10.1016/j.ocl.2012.01.005. Epub 2012 Feb 21.


The size and shape of joints markedly affect their biomechanical properties, but the macroscopic 3-dimensional (3-D) mechanism and extent of cartilage and joint maturation during normal growth are largely unknown. This study qualitatively illustrates the development of the bone-cartilage interface in the knee during postnatal growth in humans and C57BL/6 wild-type mice, quantitatively defines the 3-D shape using statistical shape modeling, and assesses growth strain rates in the mouse distal femur. Accurate quantification of the cartilage-bone interface geometry is imperative for furthering the understanding of the macroscopic mechanisms of cartilage maturation and overall joint development.

Publication types

  • Comparative Study
  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.
  • Review

MeSH terms

  • Animals
  • Animals, Newborn
  • Body Height
  • Body Weight
  • Bone Development / physiology*
  • Cartilage, Articular / diagnostic imaging
  • Cartilage, Articular / growth & development*
  • Child
  • Child, Preschool
  • Femur / diagnostic imaging
  • Femur / growth & development*
  • Humans
  • Image Processing, Computer-Assisted
  • Imaging, Three-Dimensional*
  • Infant
  • Infant, Newborn
  • Knee Joint / diagnostic imaging*
  • Mice
  • Mice, Inbred C57BL
  • Models, Animal
  • Sampling Studies
  • Species Specificity
  • Tomography, X-Ray Computed / methods