Novel phytonutrient contributors to antioxidant protection against cardiovascular disease

Nutrition. 2012 Jun;28(6):605-10. doi: 10.1016/j.nut.2011.11.028. Epub 2012 Apr 4.


The associations linking endothelial inflammation, endothelial oxidative stress, and atherogenesis and the potential for dietary phytonutrients to decrease the impact of these associations were assessed. A detailed literature review was conducted and summarized. A large body of scientific evidence describes the interactions among endothelial inflammation, endothelial oxidative stress, and atherogenesis. A growing body of research indicates that several dietary phytonutrients (astaxanthin, lycopene, lutein, and glabridin) can decrease the risk for atherosclerosis by decreasing endothelial inflammation and oxidative stress. The consumption of foods or dietary supplements that provide astaxanthin, lycopene, lutein, and glabridin can ameliorate endothelial inflammation and oxidative stress, retard atherogenesis, and decrease the risk for atherogenic cardiovascular disease.

Publication types

  • Review

MeSH terms

  • Animals
  • Anti-Inflammatory Agents / pharmacology
  • Anti-Inflammatory Agents / therapeutic use*
  • Antioxidants / pharmacology
  • Antioxidants / therapeutic use*
  • Atherosclerosis / prevention & control*
  • Carotenoids / pharmacology
  • Carotenoids / therapeutic use*
  • Diet
  • Endothelium, Vascular / drug effects*
  • Humans
  • Isoflavones / pharmacology
  • Isoflavones / therapeutic use*
  • Phenols / pharmacology
  • Phenols / therapeutic use*
  • Phytotherapy*
  • Plant Extracts / pharmacology
  • Plant Extracts / therapeutic use


  • Anti-Inflammatory Agents
  • Antioxidants
  • Isoflavones
  • Phenols
  • Plant Extracts
  • Carotenoids
  • glabridin