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, 10 (4), 349-50

Generation of Transplantable Striatal Projection Neurons From Human ESCs

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Generation of Transplantable Striatal Projection Neurons From Human ESCs

Malin Parmar et al. Cell Stem Cell.

Abstract

In this issue of Cell Stem Cell, Ma et al. (2012) report a differentiation protocol for generating striatal projection neurons from human embryonic stem cells with high efficiency. The cells survive transplantation, reconnect striatal circuitry, and restore motor function in a mouse model of striatal neurodegeneration that mimics the central pathohology of Huntington's disease.

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    Chen G, Wernig M, Berninger B, Nakafuku M, Parmar M, Zhang CL. Chen G, et al. eNeuro. 2015 Nov 9;2(5):ENEURO.0106-15.2015. doi: 10.1523/ENEURO.0106-15.2015. eCollection 2015 Sep-Oct. eNeuro. 2015. PMID: 26730402 Free PMC article. Review.

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